客户科研成果列表


基因合成 | 基因克隆 | CRISPR-Cas9 sgRNA | 密码子优化| 引物合成| 探针合成| 测序| 载体构建| DNA存储| RNA干扰| RNA合成| 慢病毒包装

基因合成

  1. Huang, J., Zha, W., An, T. et al. Appl Microbiol Biotechnol (2019) 103: 7029. Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid doi:10.1007/s00253-019-10004-z
  2. Wang, Z.-P.; Zhang, L.-L.; Liu, S.; Liu, X.-Y.; Yu, X.-J. Whole Conversion of Soybean Molasses into Isomaltulose and Ethanol by Combining Enzymatic Hydrolysis and Successive Selective Fermentations. Biomolecules 2019, 9, 353. doi: 10.3390/biom9080353
  3. Moog, D., Schmitt, J., Senger, J. et al. Using a marine microalga as a chassis for polyethylene terephthalate (PET) degradation Microb Cell Fact (2019) 18: 171.doi:10.1186/s12934-019-1220-z
  4. Proietti, S.; Falconieri, G.S.; Bertini, L.; Baccelli, I.; Paccosi, E.; Belardo, A.; Timperio, A.M.; Caruso, C. GLYI4 Plays A Role in Methylglyoxal Detoxification and Jasmonate-Mediated Stress Responses in Arabidopsis thaliana. Biomolecules 2019, 9, 635 doi:10.3390/biom9100635
  5. Xu Y , Li Y , Zhang L , et al. Unraveling the specific regulation of the shikimate pathway for tyrosine accumulation in Bacillus licheniformis[J]. Journal of Industrial Microbiology and Biotechnology, 2019, 46(8).doi:10.1007/s10295-019-02213-2
  6. Peng C., et al. Selective carboxylation of substituted phenols with engineered Escherichia coli whole-cells. Tetrahedron Letters, September, 2018. doi: 10.1016/j.tetlet.2018.09.019.
  7. Jian S., et al. Determining Allele-Specific Protein Expression (ASPE) Using a Novel QconCAT-Based Proteomics Method. Journal of Proteome Research, August 24th, 2018. doi: 10.1021/acs.jproteome.8b00620.
  8. Jinghua W., et al. CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia. Journal of Hematology & Oncology, 2018. 11:7. Doi: 10.1186/s13045-017-0553-5.
  9. Gong S., Wu C. Generation of Fabs-in-Tandem Immunoglobulin Molecules for Dual-Specific Targeting. Methods, Aug 3, 2018. pii: S1046-2023(18)30105-1. doi: 10.1016/j.ymeth.2018.07.014.
  10. Xiu, H., et al., microRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147. Journal of Cancer. 2018; 9(15):2603-2611. doi:10.7150/jca.24918.
  11. Yang, X., et al., Expression of phosphotransacetylase in Rhodosporidium toruloides leading to improved cell growth and lipid production. Royal Society of Chemistry, 10th July 2018. 8:24673-24678. doi: 10.1039/C8RA03028F.
  12. Shi, J., et al., A novel QconCAT-based proteomics method for determining allele-specific protein expression (ASPE): a new approach to identify cis-acting genetic variants. BioRxiv, 2018. doi: 10.1101/264614.
  13. Su, J., et al., Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding. Glycobiology, 2018. 28(3): p. 159-168. doi:0.1093/glycob/cwx107
  14. Wang, X., et al., Visualizing soluble protein mutants by using monomeric red fluorescent protein as a reporter for directed evolution. Applied Biochemistry and Biotechnology, 2018. 185(1): p.81-90. doi: 10.1007/ s12010-017-2640-z.
  15. Lu, H., et al., Identification of a L-Lactate dehydrogenase with 3, 4-dihydroxyphenylpyruvic reduction activity for L-Danshensu production. Process Biochemistry, 2018. doi: 10.1016/j.procbio.2018.06.011
  16. Jin, W., et al., Increased soluble heterologous expression of a rat brain 3-O-sulfotransferase 1 – A key enzyme for heparin biosynthesis. Protein Expression and Purification, 2018, Vol.151, P.23-29. doi: 10.1016/j.pep.2018.06.007
  17. Li J, Zhang Y, Zhang Y, et al. GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation[J]. Redox biology, 2018. doi.org/10.1016/j.redox.2018.04.021
  18. Cheng Y, Chen G, Wang L, et al. Triptolide-induced mitochondrial damage dysregulates fatty acid metabolism in mouse sertoli cell s[J]. Toxicology letters, 2018, 292: 136-150. doi: 10.1016/j.toxlet.2018.04.035.
  19. Pan Y, Sun H, Hu X, et al. The inhibitory role of miR 485 5p in colorectal cancer proliferation and invasion via targeting of CD147 [J]. Oncology reports, 2018, 39(5): 2201-2208. doi: 10.3892/or.2018.6309.
  20. Zhang W, He Z, Yi L, et al. A dual-functional microfluidic chip for on-line detection of interleukin-8 based on rolling circle amplification[J]. Biosensors and Bioelectronics, 2018, 102: 652-660. doi: 10.1016/j.bios.2017.12.017.
  21. Chang Z, Meng F, Zhang Z, et al. MicroRNA‐193b‐3p regulates matrix metalloproteinase 19 expression in interleukin‐1β‐induced human chondrocytes[J]. Journal of cellular biochemistry, 2018, 119(6): 4775-4782. doi: 10.1002/jcb.26669.
  22. He, P., et al., Development and application of a duplex real-time RT-PCR assay for simultaneous detection of coxsackievirus A6 and coxsackievirus A10. Annals of Clinical and Laboratory Science, 2017. 47(2): p. 178-183. PMID: 28442520
  23. Wang, Li., et al., Increased processivity, misincorporation, and nucleotide incorporation efficiency in Sulfolobus solfataricus Dpo4 thumb domain mutants. Applied and Environmental Microbiology, 2017. 83(18): p. e01013-17. doi: 10.1128/AEM.01013-17.
  24. Wang, X., et al., Engineering Escherichia coli nicotinic acid mononucleotide adenylyltransferase for fully active amidated NAD biosynthesis. Applied and Environmental Microbiology, 2017. 83(13): p. e00692-17. doi: 10.1128/AEM.00692-17.
  25. Xie, Z., et al., Design and chemical synthesis of eukaryotic chromosomes. Chemical Society Reviews, 2017. 46(23): p. 7191-7207. doi:10.1039/ c7cs00208ds
  26. Dai, S., et al., HNRNPA2B1 regulates the epithelial-mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway. Cancer Cell Int, 2017. 17: p. 12. doi: 10.1186/s12935-016-0368-4.
  27. Jin, L., et al., Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells. Biomed Pharmacother, 2017. 85: p. 287-295. doi: 10.1016/j.biopha.2016.11.023.
  28. Li, N., et al., A DNA-directed covalent conjugation fluorescence probe for in vitro detection of functional matrix metalloproteinases. Analyst, 2017. doi: 10.1039/C6AN02339H
  29. Liu J, Chen W, Zhang H, et al. miR 214 targets the PTEN mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer[J]. Oncology letters, 2017, 14(5): 5711-5718. doi: 10.3892/ol.2017.6953
  30. Duan L, Ding W, Liu X, et al. Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae[J]. Microbial cell factories, 2017, 16(1): 165. doi: 10.1186/s12934-017-0774-x
  31. Zhao Z, Xue J, Song Y, et al. Downregulated long non coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells[J]. Oncology letters, 2017, 14(5): 6143-6150. doi: 10.3892/ol.2017.6977
  32. Si, X., et al., Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion. Oncotarget, 2016. 7(47): p. 78095-78109. doi: 10.18632/ oncotarget.12947.
  33. Na, R., et al., Indentification of vincamine indole alkaloids producing endophytic fungi isolated from Nerium indicum, Apocynaceae. Microbiol Res, 2016. 192: p. 114-21. doi: 10.1016/j.micres.2016.06.008.
  34. Pan, X., et al., Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370. Am J Cancer Res, 2016. 6(12): p. 2919-2931. PMCID: PMC5199765
  35. Li, Z., et al., NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1. Biochem Biophys Res Commun, 2016. 475(1): p. 133-9. doi: 10.1016/j.bbrc.2016.05.056.
  36. Yang, H., et al., Optimized expression of prolyl aminopeptidase in Pichia pastoris and its characteristics after glycosylation. World J Microbiol Biotechnol, 2016. 32(11): p. 176. doi: 10.1007/s11274-016-2135-z.
  37. Tang, Y., et al., Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells. J Exp Clin Cancer Res, 2016. 35: p. 7.doi: 10.1186/s13046-016-0285-3
  38. Zhi N, Wan Z, Liu X, et al. Codon optimization of human parvovirus B19 capsid genes greatly increases their expression in nonpermissive cells[J]. Journal of virology, 2010, 84(24): 13059-13062.doi: 10.1128/JVI.00912-10

基因克隆

  1. Hu, J., et al., Clone and functional analysis of Seryl-tRNA synthetase and Tyrosyl-tRNA synthetase from silkworm, Bombyx mori. Sci Rep, 2017. 7: p. 41563. doi: 10.1038/srep41563.
  2. Yan, H., et al., CRIF1 enhances p53 activity via the chromatin remodeler SNF5 in the HCT116 colon cancer cell lines. BBA – Gene Regulatory Mechanisms.doi: 10.1016/j.bbagrm

CRISPR-Cas9 sgRNA

  1. Lei HQ, Wang ZF, Jiang DG, et al. CRISPR screening identififies CDK12 as a conservative vulnerability of prostate cancer. Cell Death Dis. 2021. doi: 10.1038/s41419-021-04027-6
  2. Xu P, Liu ZH, Liu Y, et al. Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. Nature Biotechnology. 2021.doi: 10.1038/s41587-021-00944-1
  3. Zhu SY, Liu Y, Zhou Z, et al. Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry. 2021.doi: 10.1007/s11427-021-1990-5
  4. Liu XJ, Liu TT, Shang YF, et al. ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Cell Reaserch. 2020.doi: 10.1038/s41422-020-0328-3
  5. Chen A, Wen SJ, Liu F, et al. CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer. Cancer Communication. 2021.doi: 10.1002/cac2.12125
  6. Bam Q, Yang P, Chou SJ, et al. Supramolecular Nanosubstrate-Mediated Delivery for CRISPR/Cas9 Gene Disruption and Deletion. Nano.micro.Small. 2021.doi: 10.1002/smll.202100546
  7. Zhou J, Yin LJ, Dong YA, et al. CRISPR-Cas13a based bacterial detection platform: Sensing pathogen Staphylococcus aureus in food samples. Analytica Chimica Acta. 2020.doi: 10.1016/j.aca.2020.06.041
  8. Nan YL, Ouyang LM, Chu J. In vitro CRISPR/Cas9 system for genome editing of Aspergillus niger based on removable bidirectional selection marker AmdS. Biotechnol Appl Biochem. 2020. doi: 10.1002/bab.1996
  9. Wang BK, Li N, Huang SY, et al. Enhanced soluble sugar content in tomato fruit using CRISPR/Cas9-mediated SlINVINH1 and SlVPE5 gene editing. PeerJ. 2021. doi: 10.7717/peerj.12478
  10. Tan G, Lin CJ, Huang CY, et al. Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E. Cancer Lett. 2022. doi: 10.1016/j.canlet.2021.12.034
  11. Cao CC, Ma Q, Huang XB, et al. Targeted Demethylation of the PLOD2 mRNA Inhibits the Proliferation and Migration of Renal Cell Carcinoma.Frontiers in Molecular Biosciences, 2020. doi: 10.3389/fmolb.2021.675683
  12. Dong T, Zhang SY, Chang Y, et al. The establishment of a homozygous SNTA1 knockout human embryonic stem cell line (WAe009-A-50) using the CRISPR/Cas9 system. Stem Cell Research. 2021.doi: 10.1016/j.scr.2021.102196
  13. Zhou YY, Lin L, Wang H, et al. Development of a CRISPR/Cas9n-based tool for metabolic engineering of Pseudomonas putida for ferulic acid-to-polyhydroxyalkanoate bioconversion. Communications Biology. 2020.doi: 10.1038/s42003-020-0824-5
  14. Wu FJ, Li Xw, Bai R, et al. Generation of a Junctophilin-2 homozygous knockout human embryonic stem cell line (WAe009-A-36) by an episomal vector-based CRISPR/Cas9 system. Stem Cell Research. 2020.doi: 10.1016/j.scr.2020.101930
  15. Triozzi P, Schmidt HW, Dervinis C, et al. Simple, efficient and open-source CRISPR/Cas9 strategy for multi-site genome editing in Populus tremula × alba. Tree Physiology. 2021.doi: 10.1093/treephys/tpab066
  16. Yankun Y, Guoqiang L, Xiao C,et al. High efficiency CRISPR/Cas9 genome editing system with an eliminable episomal sgRNA plasmid in Pichia pastoris.Enzyme and Microbial Technology, Volume 138, August 2020. doi:10.1016/j.enzmictec.2020.109556
  17. Zhu M , Sun L , Lu X , et al. Establishment of a transient CRISPR-Cas9 genome editing system in Candida glycerinogenes for co-production of ethanol and xylonic acid[J]. Journal of Bioscience and Bioengineering, 2019.doi:10.1016/j.jbiosc.2019.03.009
  18. Li J, Chen Z, Chen F, et al. Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein[J]. bioRxiv, 2019: 614859. doi:10.1101/614859
  19. Zheng S, Liu Q, Ma R, et al. Let‐7b‐5p inhibits proliferation and motility in squamous cell carcinoma cells through negative modulation of KIAA1377[J]. Cell biology international, 2019. doi:10.1002/cbin.11136
  20. Ortega-Escalante JA, Jasper R and Miller SM. CRISPR/Cas9 mutagenesis in Volvox carteri. The Plant Journal. 2019. doi: 10.1111/tpj.14149
  21. Shi TQ, Gao J, Wang WJ, et al. CRISPR/Cas9-based genome-editing in the filamentous fungus Fusarium fujikuroi and its application in strain engineering for gibberellic acid production. ACS Synthetic Biology. 2019. doi: 10.1021/acssynbio.8b00478
  22. Dai XF, Cheng HY, Chen X, et al. FOXA1 is Prognostic of Triple Negative Breast Cancers by Transcriptionally Suppressing SOD2 and IL6. International Journal of Biological Sciences. 2019. doi: 10.7150/ijbs.31009
  23. Jiao A, Zhang Y, Liu XJ, et al. Developing a CRISPR/Cas9 system for genome editing in the basidiomycetous yeast Rhodosporidium toruloides. Biotechnol J. 2019.doi: 10.1002/biot.201900036
  24. Chen L, Bao F, Tang SX, et al. PpAKR1A, a Novel Aldo-Keto Reductase from Physcomitrella Patens, Plays a Positive Role in Salt Stress. International Journal of Molecular Sciences. 2019.doi: 10.3390/ijms20225723

密码子优化

  1. Liu, B., et al., Codon optimization significantly enhanced the expression of human 37-kDa iLRP in Escherichia coli. Biotech, 2018. 8(4): p. 210. doi:10.1007/s13205-018-1234-y.
  2. Jin, W., et al., Increased soluble heterologous expression of a rat brain 3-O-sulfotransferase 1 – A key enzyme for heparin biosynthesis. Protein Expression and Purification, 2018, Vol.151, P.23-29. doi: 10.1016/j.pep.2018.06.007
  3. Peng, Z., et al., High and efficient isomaltulose production using an engineered Yarrowia lipolytica strain. Bioresource Technology, June, 2018. doi: 10.1016/j.biortech.2018.06.081

引物合成

  1. Y Li , X Wang , J Li , Y Wang, J Song … J Zhao (2019)Effects of struvite-humic acid loaded biochar/bentonite composite amendment on Zn(II) and antibiotic resistance genes in manure-soil Chemical Engineering JournalVolume 375, 1 November 2019, doi:10.1016/j.cej.2019.122013
  2. H Zhang , J Sun , Y Yan , 1, S Cui , H Wang, Cheng H ,Wang… Q Zhang (2019)Encapsulated microRNA by gemcitabine prodrug for cancer treatment Journal of Controlled Release Volume 316, 28 December 2019, Pages 317-330 doi:10.1016/j.jconrel.2019.11.010
  3. Chen, M; Wu, Y2; Yu, S; Liu, S; Wang, Y; Huang, D; Xu, X; Lin, F(2019)Drug Resistance and Integron Genes in Escherichia coli Isolated from Urinary Tract Infection Journal of Nanoscience and Nanotechnology, Volume 19, Number 9, September 2019, pp. doi:10.1166/jnn.2019.16501
  4. Haiying N., et al., Role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells. Oncology Letters, September 28th, 2018. doi: 10.3892/ol.2018.9521.
  5. Jian W., et al., Amphiregulin potentiates airway inflammation and mucus hypersecretion induced by urban particulate matter via the EGFR-PI3Kα-AKT/ERK pathway. Cellular Signalling, January, 2019. doi: 10.1016/j.cellsig.2018.10.002.
  6. Fang, B., et al., Luteolin inhibits angiogenesis of the M2‑like TAMs via the downregulation of hypoxia inducible factor‑1α and the STAT3 signalling pathway under hypoxia. Molecular Medicine Reports, July 3, 2018. doi: 10.3892/mmr.2018.9250.
  7. Chen, S., et al. Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1. Journal of Biology Chemistry, 2018. doi: 10.1074/jbc.R A117.001432.
  8. Sun, Y., et al., Effect on the liver cancer cell invasion ability by studying the associations between autophagy and TRAP1 expression. Oncology Letters, 2018. doi: 10.3892/ol.2018.8774
  9. Wang, J., et al., Transcriptome profiling reveals PHLDA1 as a novel molecular marker for ischemic cardiomyopathy. Journal of Molecular Neuroscience, 2018. 65(1): p. 102-109. doi: 10.1007/s12031-018-1066-6.
  10. Zhang, H., et al., Genetic polymorphism in the RYR1 C6487T Is associated with severity of hypospadias in Chinese Han Children. BioMed Research International, 2018. Article ID 7397839. doi: 10.1155/2018/7397839.
  11. Wang, J., et al., Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway. Journal of Thoracic Disease, 2017. 9(11): p. 4398-4412. doi: 10.21037/jtd.2017.09.135.
  12. Yu, D., et al., Quercetin inhibits epithelial-mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial-mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells. OncoTargets and Therapy, 2017. 10: p. 4719-4729. doi: 10.2147/OTT.S136840.
  13. Zhang, Z., et al., Non-invasive detection of gastric cancer relevant D-amino acids with luminescent DNA/silver nanoclusters. Nanoscale, 2017. 9(48): p. 19367-19373. doi: 10.1039/c7nr07337b.
  14. Zhang, Y., et al., Genetic and immune features of resectable malignant brainstem gliomas. Oncotarget, 2017. 8(47): p. 82571-82582. doi: 10.18632/oncotarget.19653.
  15. Wang, Q., et al., Physcion 8-O-β-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells. Biomedicine & Pharmacotherapy, 2016. 83: p. 372-380. doi:10.1016/j.biopha.2016.06.045.

探针合成

  1. Eastwood, M., et al., MicroRNA 200b is upregulated in the lungs of fetal rabbits with surgically induced diaphragmatic hernia. Prenatal Diagnosis, 2018. doi: 10.1002/pd.5318.
  2. Wu, Y., et al. A cyclic catalysis enhanced electrochemiluminescence aptasensor based 3D graphene/photocatalysts Cu2O-MWCNTs. Electochimica Acta, 2018. 282: p. 672-679. doi:10.1016/ j.electacta.2018.06.104.
  3. Zhang, Y., et al., Genetic and immune features of resectable malignant brainstem gliomas. Oncotarget, 2017. 8(47): p. 82571-82582. doi: 10. 18632/oncotarget.19653.

测序

  1. S Li, Z Wang, L Wang …S Zhao (2019)Combined enzymatic hydrolysis and selective fermentation for green production of alginate oligosaccharides from Laminaria japonica Bioresource Technology Volume 281, June 2019, Pages 84-89 doi:10.1016/j.biortech.2019.0
  2. X Zhang, L Sun, M Li, …Y Ma, C Wang, S Huang,M Ma(2019)Identification of the Novel Host Protein Interacting With the Structural Protein VP1 of Chinese Sacbrood Virus by Yeast Two-Hybrid Screening Front. Microbiol.doi:10.3389/fmicb.2019.02192
  3. Chen, M., et al., Molecular cloning and characterization of C1 tetrahydrofolate (C1-THF) synthase in Bombyx mori, silkworm. Gene, 2018. 663: p. 25-33. doi:10.1016/j.gene.2018.04.037
  4. Yang, F., et al., Local polyploidy phenomenon in Escherichia coli and its significance in genetic engineering. BioRxiv, 2018. doi: 10.1101/335448
  5. Cheng, H., et al., The hyperthermophilic α-amylase from Thermococcus sp. HJ21 does not require exogenous calcium for thermostability because of high-binding affinity to calcium. Journal of Microbiology, 2017. 55(5): p. 379-387.doi: 10.1007/s12275-017-6416-5.

载体构建

  1. Julien R，Marie G，Alain M (2019).Identification of a crucial amino acid implicated in the hydroxylation/desaturation ratio of CpFAH12 bifunctional hydroxylase.Biotechnology and Bioengineering ,Pages 2451-2462 doi:10.1002/bit.27102
  2. S Hu, G Mao, Z Zhang, P Wu, X Wen, W Liao, Z Zhang(2019).MicroRNA-320c inhibits development of osteoarthritis through downregulation of canonical Wnt signaling pathway Life Sciences, Pages 242-250 doi:10.1016/j.lfs.2019.05.011
  3. He X, Meng F, Qin L, Liu Z, Zhu X, Yu Z, Zheng Y(2019).KLK11 suppresses cellular proliferation via inhibition of Wnt/β-catenin signaling pathway in esophageal squamous cell carcinoma. Am J Cancer Res. 2019; 9(10): 2264–2277. PMID: 31720087
  4. Li, J., He, J., Wang, Y., Shu, Y., & Zhou, J. (2019). SMC1 promotes proliferation and inhibits apoptosis through the NF‑κB signaling pathway in colorectal cancer. Oncology Reports, 42, 1329-1342. doi:10.3892/or.2019.7273
  5. Chu J., et al., MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem Cells. Cell Physiol Biochem. 18th Jul 2018. 48(2): p.593-604. doi: 10.1159/000491888.
  6. Bellido, F., et al., Association between germline mutations in BRF1, a subunit of the RNA polymerase III transcription complex, and hereditary colorectal cancer. Gastroenterology, 2018. 154(1): p. 181-194. doi: 10.1053/j.gastro.2017.09.005.
  7. Xu, X., et al., Downregulation of HuR inhibits the progression of esophageal cancer through interleukin-18. Cancer Res Treat, 2018. 50(1): p.71-87. doi: 10.4143/crt.2017.013.

DNA存储

  1. Wang, Q.,Sun, J., Diao, W., et al. Digital Information Storage on DNA in Living Organisms. Medical Research Archives. vol 7, issue 6. June 2019. doi:10.18103/mra.v7i6.1930
  2. Zhong, C., et al., A new digital information storing and reading system based on synthetic DNA. Science China. Life Sciences, 2018. 6: p. 1-3. doi: 10.1007/s11427-017-9131-7.

RNA干扰

  1. Ren, Y., et al., Role of c-Abl- GSK3β signaling in MPP+-induced autophagy-lysosomal dysfunction. Toxicological Sciences, 2018. kfy155. doi:10.1093/toxsci/kfy155.

RNA合成

  1. Wang L, Song L, Li J, et al. Bone sialoprotein‐αvβ3 integrin axis promotes breast cancer metastasis to the bone. Cancer Sci. 2019;110:3157–3172. doi:10.1111/cas.14172

慢病毒包装

  1. Zhou, K; Chen, J, Wu, J; Xu, Y… Tu, W; Yang, G; Jiang, S(2019)Profilin 2 Promotes Proliferation and Metastasis of Head and Neck Cancer Cells by Regulating PI3K/AKT/β-Catenin Signaling Pathway Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Volume 27, Number 9. doi:10.3727/096504019X15579146061957

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